Antibodies - Revision history

Marcin: /* Thoughts */

2020-04-06T03:15:52Z

Thoughts

← Older revision		Revision as of 03:15, 6 April 2020
Line 5:		Line 5:
	*Are monoclonal antibodies safe? They naturally have to be tested, just like anything else. [https://www.ncbi.nlm.nih.gov/pubmed/20615177]		*Are monoclonal antibodies safe? They naturally have to be tested, just like anything else. [https://www.ncbi.nlm.nih.gov/pubmed/20615177]
	*Once a hybridoma is available, does it produce reliable results? There is a process - [https://www.researchgate.net/post/How_should_I_culture_hybridoma_cells_for_antibody_collection]		*Once a hybridoma is available, does it produce reliable results? There is a process - [https://www.researchgate.net/post/How_should_I_culture_hybridoma_cells_for_antibody_collection]
			*It is not known how well antibodies provide immunity, or heal the sick. [https://www.sciencenews.org/article/coronavirus-covid-19-can-plasma-recovered-patients-treat-sick]. Immunity is likely - but healing would be the more important short term for preventing death. Because antibodies only last up to a month.

	=Companies Working on It=		=Companies Working on It=
	*GigaGen - [https://www.fiercebiotech.com/biotech/gigagen-jumps-into-covid-19-arena-polyclonal-antibodies] - ''uses single-cell sequencing to “capture and recreate” whole libraries of antibodies from recovered COVID-19 patients. The company can then choose which of those antibodies to turn into recombinant polyclonal antibody treatments''		*GigaGen - [https://www.fiercebiotech.com/biotech/gigagen-jumps-into-covid-19-arena-polyclonal-antibodies] - ''uses single-cell sequencing to “capture and recreate” whole libraries of antibodies from recovered COVID-19 patients. The company can then choose which of those antibodies to turn into recombinant polyclonal antibody treatments''

Marcin: /* Companies Working on It */

2020-04-06T03:12:24Z

Companies Working on It

← Older revision		Revision as of 03:12, 6 April 2020
Line 8:		Line 8:
	*GigaGen - [https://www.fiercebiotech.com/biotech/gigagen-jumps-into-covid-19-arena-polyclonal-antibodies] - ''uses single-cell sequencing to “capture and recreate” whole libraries of antibodies from recovered COVID-19 patients. The company can then choose which of those antibodies to turn into recombinant polyclonal antibody treatments''		*GigaGen - [https://www.fiercebiotech.com/biotech/gigagen-jumps-into-covid-19-arena-polyclonal-antibodies] - ''uses single-cell sequencing to “capture and recreate” whole libraries of antibodies from recovered COVID-19 patients. The company can then choose which of those antibodies to turn into recombinant polyclonal antibody treatments''
	*Regeneron - ''All coronaviruses have a cell surface protein called the spike protein. It helps the virus binds to the host cell for an infection. Regeneron’s SARS-CoV-2 antibodies will target the spike protein in an attempt to block the interaction of the virus with the host.'' - [https://www.fiercebiotech.com/research/fast-moving-regeneron-eyes-summer-clinical-trial-for-covid-19-antibody-cocktail-therapy]		*Regeneron - ''All coronaviruses have a cell surface protein called the spike protein. It helps the virus binds to the host cell for an infection. Regeneron’s SARS-CoV-2 antibodies will target the spike protein in an attempt to block the interaction of the virus with the host.'' - [https://www.fiercebiotech.com/research/fast-moving-regeneron-eyes-summer-clinical-trial-for-covid-19-antibody-cocktail-therapy]
			*Scripps - one antibody is CR3022. [https://www.sciencedaily.com/releases/2020/04/200403103959.htm]

	=Definitions=		=Definitions=

Marcin: /* Definitions */

2020-04-06T03:06:27Z

Definitions

← Older revision		Revision as of 03:06, 6 April 2020
Line 14:		Line 14:
	*Recombinant antibodies - [''ecombinant antibodies are produced in vitro by cloning antibody genes for immune-specific heavy and light antibody chains into high-yield expression vectors'' - [https://www.abcam.com/primary-antibodies/recombinant-antibodies]		*Recombinant antibodies - [''ecombinant antibodies are produced in vitro by cloning antibody genes for immune-specific heavy and light antibody chains into high-yield expression vectors'' - [https://www.abcam.com/primary-antibodies/recombinant-antibodies]
	*Serological (antibody) vs PCR tests for COVID - [https://www.healthline.com/health-news/how-antibody-testing-can-help-us-fight-covid-19#What-is-an-immunity-test?]		*Serological (antibody) vs PCR tests for COVID - [https://www.healthline.com/health-news/how-antibody-testing-can-help-us-fight-covid-19#What-is-an-immunity-test?]
	*Convalescent serum - antibody-rich serum from blood of recovered patients - [https://www.merriam-webster.com/dictionary/convalescent%20serum]. But convalescent sera are more effective for preventing disease rather than for treating disease. [https://www.jci.org/articles/view/138003/figure/1]		*Convalescent serum - antibody-rich serum from blood of recovered patients - [https://www.merriam-webster.com/dictionary/convalescent%20serum]. But convalescent sera are more effective for preventing disease rather than for treating disease. [https://www.jci.org/articles/view/138003/figure/1]. '' As an example, passive antibody therapy for pneumococcal pneumonia was most effective when administered shortly after the onset of symptoms, and there was no benefit if antibody administration was delayed past the third day of disease.''
	*Prophylaxis - prevention. [https://en.wikipedia.org/wiki/Preventive_healthcare]		*Prophylaxis - prevention. [https://en.wikipedia.org/wiki/Preventive_healthcare]

Marcin: /* Definitions */

2020-04-06T03:05:37Z

Definitions

← Older revision		Revision as of 03:05, 6 April 2020
Line 15:		Line 15:
	*Serological (antibody) vs PCR tests for COVID - [https://www.healthline.com/health-news/how-antibody-testing-can-help-us-fight-covid-19#What-is-an-immunity-test?]		*Serological (antibody) vs PCR tests for COVID - [https://www.healthline.com/health-news/how-antibody-testing-can-help-us-fight-covid-19#What-is-an-immunity-test?]
	*Convalescent serum - antibody-rich serum from blood of recovered patients - [https://www.merriam-webster.com/dictionary/convalescent%20serum]. But convalescent sera are more effective for preventing disease rather than for treating disease. [https://www.jci.org/articles/view/138003/figure/1]		*Convalescent serum - antibody-rich serum from blood of recovered patients - [https://www.merriam-webster.com/dictionary/convalescent%20serum]. But convalescent sera are more effective for preventing disease rather than for treating disease. [https://www.jci.org/articles/view/138003/figure/1]
			*Prophylaxis - prevention. [https://en.wikipedia.org/wiki/Preventive_healthcare]

Marcin: /* Definitions */

2020-04-06T03:04:34Z

Definitions

← Older revision		Revision as of 03:04, 6 April 2020
Line 14:		Line 14:
	*Recombinant antibodies - [''ecombinant antibodies are produced in vitro by cloning antibody genes for immune-specific heavy and light antibody chains into high-yield expression vectors'' - [https://www.abcam.com/primary-antibodies/recombinant-antibodies]		*Recombinant antibodies - [''ecombinant antibodies are produced in vitro by cloning antibody genes for immune-specific heavy and light antibody chains into high-yield expression vectors'' - [https://www.abcam.com/primary-antibodies/recombinant-antibodies]
	*Serological (antibody) vs PCR tests for COVID - [https://www.healthline.com/health-news/how-antibody-testing-can-help-us-fight-covid-19#What-is-an-immunity-test?]		*Serological (antibody) vs PCR tests for COVID - [https://www.healthline.com/health-news/how-antibody-testing-can-help-us-fight-covid-19#What-is-an-immunity-test?]
	*Convalescent serum - antibody-rich serum from blood of recovered patients - [https://www.merriam-webster.com/dictionary/convalescent%20serum]		*Convalescent serum - antibody-rich serum from blood of recovered patients - [https://www.merriam-webster.com/dictionary/convalescent%20serum]. But convalescent sera are more effective for preventing disease rather than for treating disease. [https://www.jci.org/articles/view/138003/figure/1]

Marcin: /* Definitions */

2020-04-06T02:54:58Z

Definitions

← Older revision		Revision as of 02:54, 6 April 2020
Line 14:		Line 14:
	*Recombinant antibodies - [''ecombinant antibodies are produced in vitro by cloning antibody genes for immune-specific heavy and light antibody chains into high-yield expression vectors'' - [https://www.abcam.com/primary-antibodies/recombinant-antibodies]		*Recombinant antibodies - [''ecombinant antibodies are produced in vitro by cloning antibody genes for immune-specific heavy and light antibody chains into high-yield expression vectors'' - [https://www.abcam.com/primary-antibodies/recombinant-antibodies]
	*Serological (antibody) vs PCR tests for COVID - [https://www.healthline.com/health-news/how-antibody-testing-can-help-us-fight-covid-19#What-is-an-immunity-test?]		*Serological (antibody) vs PCR tests for COVID - [https://www.healthline.com/health-news/how-antibody-testing-can-help-us-fight-covid-19#What-is-an-immunity-test?]
	*Convalescent serum - [https://www.merriam-webster.com/dictionary/convalescent%20serum]		*Convalescent serum - antibody-rich serum from blood of recovered patients - [https://www.merriam-webster.com/dictionary/convalescent%20serum]

Marcin: /* Definitions */

2020-04-06T02:54:36Z

Definitions

← Older revision		Revision as of 02:54, 6 April 2020
Line 14:		Line 14:
	*Recombinant antibodies - [''ecombinant antibodies are produced in vitro by cloning antibody genes for immune-specific heavy and light antibody chains into high-yield expression vectors'' - [https://www.abcam.com/primary-antibodies/recombinant-antibodies]		*Recombinant antibodies - [''ecombinant antibodies are produced in vitro by cloning antibody genes for immune-specific heavy and light antibody chains into high-yield expression vectors'' - [https://www.abcam.com/primary-antibodies/recombinant-antibodies]
	*Serological (antibody) vs PCR tests for COVID - [https://www.healthline.com/health-news/how-antibody-testing-can-help-us-fight-covid-19#What-is-an-immunity-test?]		*Serological (antibody) vs PCR tests for COVID - [https://www.healthline.com/health-news/how-antibody-testing-can-help-us-fight-covid-19#What-is-an-immunity-test?]
			*Convalescent serum - [https://www.merriam-webster.com/dictionary/convalescent%20serum]

Marcin at 02:52, 6 April 2020

2020-04-06T02:52:42Z

← Older revision		Revision as of 02:52, 6 April 2020
Line 1:		Line 1:
			=Thoughts=
	*Antibodies are blood proteins that kill cellular intruders (disease) - [https://en.wikipedia.org/wiki/Antibody]		*Antibodies are blood proteins that kill cellular intruders (disease) - [https://en.wikipedia.org/wiki/Antibody]
	*How do you culture antibodies? Via hybridomas - [https://en.wikipedia.org/wiki/Hybridoma_technology]		*How do you culture antibodies? Via hybridomas - [https://en.wikipedia.org/wiki/Hybridoma_technology]
	*'''Once a hybridoma is produced, say for the COVID spike protein - then is mass production of it distributatable via basic DIY bio?'''		*'''Once a hybridoma is produced, say for the COVID spike protein - then is mass production of it distributatable via basic DIY bio?'''
	*Are monoclonal antibodies safe? They naturally have to be tested, just like anything else. [https://www.ncbi.nlm.nih.gov/pubmed/20615177]		*Are monoclonal antibodies safe? They naturally have to be tested, just like anything else. [https://www.ncbi.nlm.nih.gov/pubmed/20615177]
			*Once a hybridoma is available, does it produce reliable results? There is a process - [https://www.researchgate.net/post/How_should_I_culture_hybridoma_cells_for_antibody_collection]
	=Companies Working on It=		=Companies Working on It=
	*GigaGen - [https://www.fiercebiotech.com/biotech/gigagen-jumps-into-covid-19-arena-polyclonal-antibodies] - ''uses single-cell sequencing to “capture and recreate” whole libraries of antibodies from recovered COVID-19 patients. The company can then choose which of those antibodies to turn into recombinant polyclonal antibody treatments''		*GigaGen - [https://www.fiercebiotech.com/biotech/gigagen-jumps-into-covid-19-arena-polyclonal-antibodies] - ''uses single-cell sequencing to “capture and recreate” whole libraries of antibodies from recovered COVID-19 patients. The company can then choose which of those antibodies to turn into recombinant polyclonal antibody treatments''

Marcin at 02:48, 6 April 2020

2020-04-06T02:48:42Z

← Older revision		Revision as of 02:48, 6 April 2020
Line 2:		Line 2:
	*How do you culture antibodies? Via hybridomas - [https://en.wikipedia.org/wiki/Hybridoma_technology]		*How do you culture antibodies? Via hybridomas - [https://en.wikipedia.org/wiki/Hybridoma_technology]
	*'''Once a hybridoma is produced, say for the COVID spike protein - then is mass production of it distributatable via basic DIY bio?'''		*'''Once a hybridoma is produced, say for the COVID spike protein - then is mass production of it distributatable via basic DIY bio?'''
			*Are monoclonal antibodies safe? They naturally have to be tested, just like anything else. [https://www.ncbi.nlm.nih.gov/pubmed/20615177]
	=Companies Working on It=		=Companies Working on It=
	*GigaGen - [https://www.fiercebiotech.com/biotech/gigagen-jumps-into-covid-19-arena-polyclonal-antibodies] - ''uses single-cell sequencing to “capture and recreate” whole libraries of antibodies from recovered COVID-19 patients. The company can then choose which of those antibodies to turn into recombinant polyclonal antibody treatments''		*GigaGen - [https://www.fiercebiotech.com/biotech/gigagen-jumps-into-covid-19-arena-polyclonal-antibodies] - ''uses single-cell sequencing to “capture and recreate” whole libraries of antibodies from recovered COVID-19 patients. The company can then choose which of those antibodies to turn into recombinant polyclonal antibody treatments''

Marcin at 02:40, 6 April 2020

2020-04-06T02:40:01Z

← Older revision		Revision as of 02:40, 6 April 2020
Line 1:		Line 1:
	*Antibodies are blood proteins that kill cellular intruders (disease) - [https://en.wikipedia.org/wiki/Antibody]		*Antibodies are blood proteins that kill cellular intruders (disease) - [https://en.wikipedia.org/wiki/Antibody]
	*How do you culture antibodies? Via hybridomas - [https://en.wikipedia.org/wiki/Hybridoma_technology]		*How do you culture antibodies? Via hybridomas - [https://en.wikipedia.org/wiki/Hybridoma_technology]
			*'''Once a hybridoma is produced, say for the COVID spike protein - then is mass production of it distributatable via basic DIY bio?'''

	=Companies Working on It=		=Companies Working on It=