Non 24-Hour Sleep Phase Disorder

• [1] - Having unstructured or irregular daily routines, bad sleeping habits, and poor exposure to sunlight on a consistent basis can all be factors in the development of this disorder.
• This is a thorough explanation of wake-sleep patterns - including SCN, melatonin, melanopsin, blindness effects, homeostasis vs extra alertness hormones, and more. [2]
  • Some people are hypersensitive to waking effects of light, some are subsensitive.
  • There is circadian rhythm and a cellular clock. Both must be correlated.
  • There is an internal clock, typically 24.2 hours, and light effects. Light reduces internal clock, to entrain with 24 hour cycles.
  • Muscle cells, in vitro, showed N24 on the cellular level (levels of activity)
  • There is an extreme evening chronotype and free-running N24. Existence of Extreme Evening Chronotype means that there are other factors contributing to clinical N24.
  • 'Deficiency in homeostatic drive for sleep'
  • Delayed sleep phase disorder- when you go to bed late and wake late, regularly. Sleep in on weekends.
  • Why not delay bedtime to get to normal cycle? Why not make bedtime early? Advantage + disadvantage? In former, we get lazy. In latter, we get sleep deprived. Which is better? Which case is true?
  • Extreme evening chronotype - you go to bed late. Make it up on weekends.
  • Social jetlag - when your sleep time is different than others
  • Circadian Sleep Disorders Network - [3]
  • Idiopathic hypersomnia - like N24, but it is caused by the sleep time being longer, with constant wake time. Byt what determines constant wake time? In N24, both sleep and wake time are longer?
  • Best treatment for sighted patients - The most widely recommended treatments for sighted patients involve exposure to specific regimens of light (phototherapy) and dark (scototherapy).
• Other notes - Idiopathic Hypersomnia [4] - sleeping too much. Cause is clear: no exercise, not waking up with light, or other various imbalances.