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  • Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N
  • It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom
  • It is a colorless, highly flammable, weakly alkaline, water-soluble liquid with a distinctive, unpleasant fish-like smell. Pyridine is colorless
  • Older or impure samples can appear yellow.
  • It is a basic industrial chemical feedstock


Chichibabin synthesis


  • This process is carried out in a gas phase at 400–450 °C with a a transition metal salt such as cadmium(II) fluoride or manganese(II) fluoride, or cobalt and thallium compound catalyst



  • First, Acrolein is formed in a Knoevenagel condensation from the acetaldehyde and formaldehyde
  • The acrolein is then condensed with acetaldehyde and ammonia to give Dihydropyridine
  • This is then oxidized with a solid-state catalyst to pyridine.


  • The product consists of a mixture of pyridine, simple methylated pyridines (picolines and lutidines);

its composition depends on the catalyst used and can be adapted to the needs of the manufacturer via changing the catalyst accoordingly

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