Non 24-Hour Sleep Phase Disorder

• [1] - Having unstructured or irregular daily routines, bad sleeping habits, and poor exposure to sunlight on a consistent basis can all be factors in the development of this disorder.
• This is a thorough explanation of wake-sleep patterns - including SCN, melatonin, melanopsin, blindness effects, homeostasis vs extra alertness hormones, and more. [2]
  • Some people are hypersensitive to waking effects of light, some are subsensitive.
  • There is circadian rhythm and a cellular clock. Both must be correlated.
  • There is an internal clock, typically 24.2 hours, and light effects. Light reduces internal clock, to entrain with 24 hour cycles.
  • Muscle cells, in vitro, showed N24 on the cellular level (levels of activity)
  • There is an extreme evening chronotype and free-running N24. Existence of Extreme Evening Chronotype means that there are other factors contributing to clinical N24.
  • 'Deficiency in homeostatic drive for sleep'