Non 24-Hour Sleep Phase Disorder

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  • [1] - Having unstructured or irregular daily routines, bad sleeping habits, and poor exposure to sunlight on a consistent basis can all be factors in the development of this disorder.
  • This is a thorough explanation of wake-sleep patterns - including SCN, melatonin, melanopsin, blindness effects, homeostasis vs extra alertness hormones, and more. [2]
    • Some people are hypersensitive to waking effects of light, some are subsensitive.
    • There is circadian rhythm and a cellular clock. Both must be correlated.
    • There is an internal clock, typically 24.2 hours, and light effects. Light reduces internal clock, to entrain with 24 hour cycles.
    • Muscle cells, in vitro, showed N24 on the cellular level (levels of activity)
    • There is an extreme evening chronotype and free-running N24. Existence of Extreme Evening Chronotype means that there are other factors contributing to clinical N24.
    • 'Deficiency in homeostatic drive for sleep'
    • Delayed sleep phase disorder- when you go to bed late and wake late, regularly. Sleep in on weekends.
    • Why not delay bedtime to get to normal cycle? Why not make bedtime early? Advantage + disadvantage? In former, we get lazy. In latter, we get sleep deprived. Which is better? Which case is true?
    • Extreme evening chronotype - you go to bed late. Make it up on weekends.
    • Social jetlag - when your sleep time is different than others
    • Circadian Sleep Disorders Network